Stock Quotes in this Article: LEE, PLD, RPTP, FIVE, INSY

DELAFIELD, Wis. (Stockpickr) -- Trading stocks that trigger major breakouts can lead to massive profits. Once a stock trends to a new high\ or takes out a prior overhead resistance point, then it's free to find new buyers and momentum players that can ultimately push the stock significantly higher.

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Breakout candidates are something that I tweet about on a daily basis. I frequently tweet out high-probability setups, breakout plays and stocks that are acting technically bullish. These are the stocks that often go on to make monster moves to the upside. What's great about breakout trading is that you focus on trend, price and volume. You don't have to concern yourself with anything else. The charts do all the talking.

Trading breakouts is not a new game on Wall Street. This strategy has been mastered by legendary traders such as William O'Neal, Stan Weinstein and Nicolas Darvas. These pros know that once a stock starts to break out above past resistance levels, and hold above those breakout prices, then it can easily trend significantly higher.

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With that in mind, here's a look at five stocks that are setting up to break out and trade higher from current levels.

Insys Therapeutics

One specialty pharmaceutical player that's quickly moving within range of triggering a big breakout trade is Insys Therapeutics (INSY), which develops and commercialize supportive care products that target the unmet needs of cancer patients, with an initial focus on cancer-supportive care. This stock is off to a monster start in 2013, with shares up a whopping 434%.

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If you take a look at the chart for Insys Therapeutics, you'll notice that this stock has been uptrending strong for the last six months, with shares soaring higher from its low of $9.30 to its recent high of $53.64 a share. During that uptrend, shares of INSY have been making mostly higher lows and higher highs, which is bullish technical price action. Shares of INSY have recently pulled back to its 50-day moving average and the stock has now started to spike higher off that level. That spike is starting to push shares of INSY within range of triggering a big breakout trade.

Traders should now look for long-biased trades in INSY if it manages to break out above some near-term overhead resistance levels at $43.50 to $44.52 a share with high volume. Look for a sustained move or close above those levels with volume that hits near or above its three-month average action of 235,266 shares. If that breakout hits soon, then INSY will set up to re-test or possibly take out its next major overhead resistance levels at $47.25 to its all-time high at $53.64 a share.

Traders can look to buy INSY off any weakness to anticipate that breakout and simply use a stop that sits right below some near-term support at $38.75 a share or near its 50-day at $36.73 a share. One can also buy INSY off strength once it takes out those breakout levels with volume and then simply use a stop that sits a comfortable percentage from your entry point.

Lee Enterprises

Another newspaper publishing player that looks ready to trigger a major breakout trade is Lee Enterprises (LEE), which is a provider of local news and information and a platform for advertising, in primarily midsize markets. This stock has been on fire so far in 2013, with shares up big by 154%.

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If you take a look at the chart for Lee Enterprises, you'll notice that this stock is just starting to spike higher back above its 50-day moving average of $2.89 a share with strong upside volume. Volume already today has registered over 360,000 shares, which is quickly approaching its three-month average action of 399,735 shares. This move is quickly pushing shares of LEE within range of triggering a major breakout trade.

Traders should now look for long-biased trades in LEE if it manages to break out above some near-term overhead resistance levels at $3.14 a share to its 52-week high at $3.20 a share with high volume. Look for a sustained move or close above those levels with volume that hits near or above its three-month average action of 399,735 shares. If that breakout hits soon, then LEE will set up to enter new 52-week-high territory, which is bullish technical price action. Some possible upside targets off that breakout are $4 to $5 a share.

Traders can look to buy LEE off any weakness to anticipate that breakout and simply use a stop that sits right below some key near-term support levels at $2.71 or at $2.60 a share. One could also buy LEE off strength once it takes out those breakout levels with volume and then simply use a stop that sits a comfortable percentage from your entry point.

Raptor Pharmaceuticals

One biotechnology player that's starting to trend within range of triggering a big breakout trade is Raptor Pharmaceuticals (RPTP), which has a pipeline that includes both candidates from its proprietary drug targeting platforms and in-licensed and acquired product candidates. This stock is in play with the bulls so far in 2013, with shares up sharply by 151%.

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If you take a look at the chart for Raptor Pharmaceuticals, you'll notice that stock has been uptrending strong for the last six months, with shares soaring higher from its low of $5.50 to its recent high of $15.29 a share. During that uptrend, shares of RPTP have been consistently making higher lows and higher highs, which is bullish technical price action. That move has now pushed shares of RPTP within range of triggering a big breakout trade.

Traders should now look for long-biased trades in RPTP if it manages to break out above some near-term overhead resistance levels at $14.99 a share to its 52-week high at $15.29 a share with high volume. Look for a sustained move or close above those levels with volume that hits near or above its three-month average volume of 844,332 shares. If that breakout triggers soon, then RPTP will set up to enter new 52-week-high territory, which is bullish technical price action. Some possible upside targets off that breakout are $18 to $20 a share, or even north of $20 a share.

Traders can look to buy RPTP off any weakness to anticipate that breakout and simply use a stop that sits right below some key near-term support levels at $13.69 a share or at $13 a share. One can also buy RPTP off strength once it takes out those breakout levels with volume and then simply use a stop that sits a comfortable percentage from your entry point.

Five Below

Another stock that's quickly pushing within range of triggering a major breakout trade is specialty retailer Five Below (FIVE), which offers merchandise targeted at the teen and pre-teen customer. This stock is off to a strong start in 2013, with shares up 54%.

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If you look at the chart for Five Below, you'll notice that this stock has been uptrending strong for the last month and change, with shares pushing higher from its low of $42.42 to its recent high of $50.39 a share. During that uptrend, shares of FIVE have been making mostly higher lows and higher highs, which is bullish technical price action. That move has now pushed shares of FIVE within range of triggering a major breakout trade.

Traders should now look for long-biased trades in FIVE if it manages to break out above its all-time high at $50.39 a share with high volume. Look for a sustained move or close above that level with volume that hits near or above its three-month average action of 835,622 shares. If that breakout triggers soon, then FIVE will set up to enter new all-time-high territory, which is bullish technical price action. Some possible upside targets off that breakout are $60 to $65 a share.

Traders can look to buy FIVE off any weakness to anticipate that breakout and simply use a stop that sits right below some key near-term support at $47.13 a share or around $46 a share. One can also buy FIVE off strength once it takes out its all-time high at $50.39 a share with volume and then simply use a stop that sits a comfortable percentage from your entry point.

Prologis

My final breakout trading prospect is industrial REIT player Prologis (PLD), a global owner, operator and developer of industrial real estate, focused on major hub and gateway distribution markets in the Americas, Europe and Asia. This stock is off to a decent start in 2013, with shares up 10.4%.

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If you look at the chart for Prologis, you'll notice that this stock recently formed a double bottom chart pattern at $37.31 to $37.33 a share. Following that bottom, shares of PLD have ripped higher right off its 50-day moving average and back above its 200-day moving average. That move has now pushed shares of PLD within range of triggering a big breakout trade.

Traders should now look for long-biased trades in PLD if it manages to break out above some near-term overhead resistance at $40.99 a share with high volume. Look for a sustained move or close above that level with volume that hits near or above its three-month average action of 2.35 million shares. If that breakout triggers soon, then PLD will set up to re-test or possibly take out its next major overhead resistance levels $44.86 to its 52-week high at $45.52 a share. Any high-volume move above those levels will then give PLD a chance to tag $50 to $60 a share.

Traders can look to buy PLD off any weakness to anticipate that breakout and simply use a stop that sits right below its 200-day moving average of $38.83 a share or near its 50-day moving average at $38.09 a share. One could also buy PLD off strength once it clears $40.99 a share with volume and then simply use a stop that sits a conformable percentage from your entry point.

To see more breakout candidates, check out the Breakout Stocks of the Week portfolio on Stockpickr.

-- Written by Roberto Pedone in Delafield, Wis.

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At the time of publication, author had no positions in stocks mentioned.

Roberto Pedone, based out of Delafield, Wis., is an independent trader who focuses on technical analysis for small- and large-cap stocks, options, futures, commodities and currencies. Roberto studied international business at the Milwaukee School of Engineering, and he spent a year overseas studying business in Lubeck, Germany. His work has appeared on financial outlets including CNBC.com and Forbes.com. You can follow Pedone on Twitter at www.twitter.com/zerosum24 or @zerosum24.