Stock Quotes in this Article: DRRX, LCAV, SMI, PACB

WINDERMERE, Fla. (Stockpickr) -- At Stockpickr, we track daily portfolios of stocks that are the biggest percentage gainers and the biggest percentage losers.

Stocks that are making large moves like these are favorites among short-term traders because they can jump into these names and try to capture some of that massive volatility. Stocks that are making big-percentage moves either up or down are usually in play because their sector is becoming attractive or they have a major fundamental catalyst such as a recent earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade.

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Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success.

With that in mind, let's take a closer look at a several stocks that are making large moves to the upside today.

>>5 Stocks Poised for Breakouts

Durect

Durect (DRRX) is a specialty pharmaceutical company that develops pharmaceutical products based on its proprietary drug delivery technology platforms. This stock is trading up 7.4% to $1.30 in recent trading.

Today’s Range: $1.21-$1.31

52-Week Range: $0.61-$1.71

Volume: 267,000

Three-Month Average Volume: 321,195

From a technical perspective, DRRX is ripping higher here right above its 50-day moving average of $1.12 with decent upside volume. This move is quickly pushing shares of DRRX within range of triggering a major breakout trade. That trade will hit if DRRX manages to take out some key overhead resistance levels at $1.38 to $1.42 with high volume.

Traders should now look for long-biased trades in DRRX as long as it’s trending above today’s low of $1.21 or above its 50-day at $1.12, and then once it sustains a move or close above those breakout levels with volume that hits near or above 321,195 shares. If that breakout triggers soon, then DRRX will set up to re-test or possibly take out its next major overhead resistance level at $1.71.

Pacific Biosciences of California

Pacific Biosciences of California (PACB), which is engaged in design, development and commercialization of innovative tools for biological research, is trading up 8.1% to $2.39 in recent trading.

Today’s Range: $2.20-$2.40

52-Week Range: $1.06-$3.99

Volume: 327,000

Three-Month Average Volume: 514,302

From a technical perspective, PACB is soaring higher here right above some near-term support at $2.16 to $2.13 with solid upside volume. This move is quickly pushing shares of PACB within range of triggering a near-term breakout trade. That trade will hit if PACB manages to take out its 50-day at $2.39 and then once it clears more overhead resistance levels at $2.64 to $2.73 with high volume.

Traders should now look for long-biased trades in PACB as long as it’s trending above $2.16, and then once it sustains a move or close above those breakout levels with volume that hits near or above 514,302 shares. If that breakout triggers soon, then PACB will set up to re-test or possibly take out its next major overhead resistance levels at $3.25 to $3.99.

LCA-Vision

LCA-Vision (LCAV) is a provider of fixed-site laser vision correction services at its LasikPlus vision centers. This stock is trading up 6.3% to $3.35 in recent trading.

Today’s Range: $3.15-$3.36

52-Week Range: $2.67-$7.50

Volume: 86,000

Three-Month Average Volume: 102,995

From a technical perspective, LCAV is ripping higher here back above its 50-day moving average of $3.14 with decent upside volume. This stock recently formed a double bottom at around $2.78 to $2.83 and it has now broken out above some near-term overhead resistance levels at $3.08 to its 50-day at $3.14. Shares of LCAV are now quickly moving within range of triggering another major breakout trade. That trade will hit if LCAV manages to take out some near-term overhead resistance levels at $3.50 to $3.60 and then once it clears its 200-day at $3.68 with high volume.

Traders should now look for long-biased trades in LCAV as long as it’s trending above its 50-day at $3.14, and then once it sustains a move or close above those breakout levels with volume that hits near or above 102,995 shares. If that breakout triggers soon, then LCAV will set up to re-test or possibly take out its next major overhead resistance levels at $4.10 to $4.32. Any high-volume move above those levels will then put $4.60 into range for shares of LCAV.

Semiconductor Manufacturing International

Semiconductor Manufacturing International (SMI) is an advanced foundry in Mainland China, providing integrated circuit foundry and technology services at 0.35-micron to 40-nanometer. This stock is trading up 5.1% to $2.85 in recent trading.

Today’s Range: $2.83-$2.89

52-Week Range: $1.47-$3.42

Volume: 140,000

Three-Month Average Volume: 193,402

From a technical perspective, SMI is bouncing higher here right above some near-term support at $2.71 with decent upside volume. This move is quickly pushing shares of SMI within range of triggering a major breakout trade. That trade will hit if SMI manages to take out some near-term overhead resistance levels at its 50-day moving average of $2.92 and then above more resistance levels at $2.96 to $3.10 with high volume.

Traders should now look for long-biased trades in SMI as long as it’s trending above $2.71, and then once it sustains a move or close above those breakout levels with volume that hits near or above 193,402 shares. If that breakout hits soon, then SMI will set up to re-test or possibly take out its next major overhead resistance level at $3.42.

To see more stocks that are making notable moves higher today, check out the Stocks Under $10 Moving Higher portfolio on Stockpickr.

-- Written by Roberto Pedone in Winderemere, Fla.

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At the time of publication, author had no positions in stocks mentioned.

Roberto Pedone, based out of Windermere, Fla., is an independent trader who focuses on technical analysis for small- and large-cap stocks, options, futures, commodities and currencies. Roberto studied international business at the Milwaukee School of Engineering, and he spent a year overseas studying business in Lubeck, Germany. His work has appeared on financial outlets including CNBC.com and Forbes.com. You can follow Pedone on Twitter at www.twitter.com/zerosum24 or @zerosum24.