Stock Quotes in this Article: ECTE, EDN, XPL, SUPN

DELAFIELD, Wis. (Stockpickr) -- At Stockpickr, we track daily portfolios of stocks that are the biggest percentage gainers and the biggest percentage losers.

>>5 Stocks Poised for Breakouts

Stocks that are making large moves like these are favorites among short-term traders because they can jump into these names and try to capture some of that massive volatility. Stocks that are making big-percentage moves either up or down are usually in play because their sector is becoming attractive or they have a major fundamental catalyst such as a recent earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade.

Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success.

>>5 Stock Charts Screaming "Buy" in March

With that in mind, let's take a closer look at a several stocks under $10 that are making large moves to the upside.

Echo Therapeutics (ECTE) operates as a transdermal medical device company in the U.S. This stock closed up 2% to $3.27 a share in Friday's trading session.

Friday's Range: $3.17-$3.28

52-Week Range: $1.80-$8.30

Friday's Volume: 197,000

Three-Month Average Volume: 223,427

From a technical perspective, ECTE spiked modestly higher here right above its 200-day moving average of $2.99 with decent upside volume. This move is quickly pushing shares of ECTE within range of triggering a big breakout trade. That trade will hit if ECTE manages to take out its 50-day moving average of $3.31 to some more near-term overheard resistance at $3.34 with high volume.

Traders should now look for long-biased trades in ECTE as long as it's trending above its 200-day at $2.99 and then once it sustains a move or close above those breakout levels with volume that hits near or above 223,427 shares. If that breakout starts soon, then ECTE will set up to re-test or possibly take out its next major overhead resistance levels at $4.02 to $4.13, or even $4.91.

Empresa Distribuidora y Comercializadora Norte (EDN), a public service company, engages in the distribution and sale of electricity in Argentina. This stock closed up 1% to $6.57 a share in Friday's trading session.

Friday's Range: $6.29-$6.60

52-Week Range: $1.85-$9.60

Friday's Volume: 37,000

Three-Month Average Volume: 74,682

From a technical perspective, EDN jumped higher here right above some near-term support at $6 with lighter-than-average volume. This spike on Friday is starting to push shares of EDN within range of triggering a near-term breakout trade. That trade will hit if EDN manages to take out Friday's high of $6.60 to some more near-term overhead resistance at $6.87 with high volume.

Traders should now look for long-biased trades in EDN as long as it's trending above some near-term support at $6 or above its 50-day moving average of $5.76 and then once it sustains a move or close above those breakout levels with volume that hits near or above 74,682 shares. If that breakout materializes soon, then EDN will set up to re-test or possibly take out its next major overhead resistance levels at $7.50 to $7.90. Any high-volume move above those levels will then give EDN a chance to tag $8 to $8.50.

Solitario Exploration & Royalty (XPL), a development stage company, engages in the acquisition and exploration of precious and base metal properties in Peru, Brazil, and Mexico. This stock closed flat at $1.55 in Friday's trading session.

Friday's Range: $1.50-$1.62

52-Week Range: $0.76-$1.67

Friday's Volume: 133,000

Three-Month Average Volume: 59,865

From a technical perspective, XPL trended flat here with above-average volume. This stock is starting to trend within range of triggering a big breakout trade. That trade will hit if XPL manages to take out some key overhead resistance levels at $1.63 to its 52-week high at $1.67 with high volume.

Traders should now look for long-biased trades in XPL as long as it's trending above some near-term support at $1.41 and then once it sustains a move or close above those breakout levels with volume that hits near or above 59,865 shares. If that breakout gets underway soon, then XPL will set up to enter new 52-week-high territory, which is bullish technical price action. Some possible upside targets off that breakout are its next major overhead resistance levels at $1.90 to $2.

Supernus Pharmaceuticals (SUPN), a specialty pharmaceutical company, develops and commercializes products for the treatment of central nervous system diseases in the U.S. This stock closed up 3.1% to $10.07 a share in Friday's trading session.

Friday's Range: $9.69-$10.16

52-Week Range: $4.45-$10.55

Friday's Volume: 950,000

Three-Month Average Volume: 673,025

From a technical perspective, SUPN spiked notably higher here with above-average volume. This spike is quickly pushing shares of SUPN within range of triggering a major breakout trade. That trade will hit if SUPN manages to take out Friday's high of $10.16 to its 52-week high at $10.55 with strong volume.

Traders should now look for long-biased trades in SUPN as long as it's trending above its 50-day moving average of $9.23 and then once it sustains a move or close above those breakout levels with volume that hits near or above 673,025 shares. If that breakout hits soon, then SUPN will set up to enter new 52-week-high territory, which is bullish technical price action. Some possible upside targets off that breakout are its next major overhead resistance levels at $13 to $14.98.

To see more stocks that are making notable moves higher, check out the Stocks Under $10 Moving Higher portfolio on Stockpickr.

-- Written by Roberto Pedone in Delafield, Wis.


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At the time of publication, author had no positions in stocks mentioned.

Roberto Pedone, based out of Delafield, Wis., is an independent trader who focuses on technical analysis for small- and large-cap stocks, options, futures, commodities and currencies. Roberto studied international business at the Milwaukee School of Engineering, and he spent a year overseas studying business in Lubeck, Germany. His work has appeared on financial outlets including

CNBC.com and Forbes.com.

You can follow Pedone on Twitter at www.twitter.com/zerosum24 or @zerosum24.