Stock Quotes in this Article: DPZ, NUS, USU, KYTH

DELAFIELD, Wis. (Stockpickr) -- Professional traders running mutual funds and hedge funds don't just look at a stock's price moves; they also track big changes in volume activity. Often when above-average volume moves into an equity, it precedes a large spike in volatility.

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Major moves in volume can signal unusual activity, such as insider buying or selling -- or buying or selling by "superinvestors."

Unusual volume can also be a major signal that hedge funds and momentum traders are piling into a stock ahead of a catalyst. These types of traders like to get in well before a large spike, so it's always a smart move to monitor unusual volume. That said, remember to combine trend and price action with unusual volume. Put them all together to help you decipher the next big trend for any stock.

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With that in mind, let's take a look at several stocks rising on unusual volume today.

Kythera Biopharmaceuticals

Kythera Biopharmaceuticals (KYTH) is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel prescription products for the aesthetic medicine market. This stock closed up 12.2% to $31.99 in Monday's trading session.

Monday's Volume: 221,000

Three-Month Average Volume: 72,572

Volume % Change: 220%

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From a technical perspective, KYTH ripped sharply higher here right above its 50-day moving average of $26.92 with heavy upside volume. This move pushed shares of KYTH into new all-time-high territory above its previous all-time high at $31.93, which is bullish technical price action.

Traders should now look for long-biased trades in KYTH as long as it's trending above Monday's low of $28.28 and then once it sustains a move or close above its new all-time high at $32 with volume that hits near or above 72,572 shares. If we get that move soon, then KYTH will set up to enter new all-time-high territory, which is bullish price action. Some possible upside targets off that move are $35 to $37.

Usec

Usec (USU) is a global energy company, which is a supplier of low enriched uranium for commercial nuclear power plants. This stock closed up 8.3% at $13.75 in Monday's trading session.

Monday's Volume: 1.57 million

Three-Month Average Volume: 651,161

Volume % Change: 227%

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From a technical perspective, USU bounced sharply higher here right off its 200-day moving average of $11.77 and back above its 50-day moving average of $13.36 with heavy upside volume. This stock has been downtrending badly for the last month, with shares moving lower from its high of $22.73 to its recent low of $12.12. During that move, shares of USU have been making mostly lower highs and lower lows, which is bearish technical price action. That said, the downside volatility might be over in the short-term for USU, since the stock has now started to bounce off key moving averages with volume.

Traders should now look for long-biased trades in USU as long as it's trending above Monday's low of $12.12 and then once it sustains a move or close above Monday's intraday high of $14.66 with volume that hits near or above 651,161 shares. If we get that move soon, then USU will set up to re-test or possibly take out its next major overhead resistance levels at $17 to $19.

Nu Skin Enterprises

Nu Skin Enterprises (NUS) is a direct selling company, which develops and distributes personal care products and nutritional supplements that are sold under the Nu Skin and Pharmanex brands. This stock closed up 5.4% at $92.96 in Monday's trading session.

Monday's Volume: 2 million

Three-Month Average Volume: 900,802

Volume % Change: 85%

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From a technical perspective, NUS ripped higher here right above some near-term support at $85 with heavy upside volume. This move pushed shares of NUS into breakout and new 52-week-high territory, since the stock took out some near-term overhead resistance levels at $88.20 to $89.69. This move also pushed shares of NUS above the upper-end of its recent range that saw the stock trend between $82 to just above $89.

Traders should now look for long-biased trades in NUS as long as it's trending above support at $85 and then once it sustains a move or close above Monday's high of $93.33 with volume that this near or above 900,802 shares. If we get that move soon, then NUS will set up to enter new 52-week-high territory, which is bullish technical price action. Some possible upside targets off that move are $100 to $105.

Domino's Pizza

Domino's Pizza (DPZ) is engaged in retail sales of food through Domino's Pizza stores; sales of equipment and supplies to Domino's Pizza stores and receipt of royalties from domestic and international Domino's Pizza franchisees. This stock closed up 2.3% at $63.04 in Monday's trading session.

Monday's Volume: 1.19 million

Three-Month Average Volume: 663,847

Volume % Change: 65%

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From a technical perspective, DPZ jumped higher here right off its 50-day moving average of $62.06 with strong upside volume. This stock has been trending sideways for the last few weeks, with shares moving between $60.86 on the downside and just over $64 on the upside. This move on Monday has now started to push shares of DPZ above the upper-end of its recent sideways trading chart pattern.

Traders should now look for long-biased trades in DPZ as long as it's trending above its 50-day at $62.06 and then once it sustains a move or close above Monday's high of $63.07 with volume that's near or above 663,847 shares. If we get that move soon, then DPZ will set up to re-test or possibly take out its 52-week high at $64.70. Any high-volume move above that level will then give DPZ a chance to tag $70.

To see more stocks rising on unusual volume, check out the Stocks Rising on Unusual Volume portfolio on Stockpickr.

-- Written by Roberto Pedone in Delafield, Wis.

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At the time of publication, author had no positions in stocks mentioned.

Roberto Pedone, based out of Delafield, Wis., is an independent trader who focuses on technical analysis for small- and large-cap stocks, options, futures, commodities and currencies. Roberto studied international business at the Milwaukee School of Engineering, and he spent a year overseas studying business in Lubeck, Germany. His work has appeared on financial outlets including CNBC.com and Forbes.com. You can follow Pedone on Twitter at www.twitter.com/zerosum24 or @zerosum24.