Stock Quotes in this Article: CUR, ENMD, OPXA, SURG

MADISON, Wis. (Stockpickr) -- At Stockpickr, we track daily portfolios of stocks that are the biggest percentage gainers and the biggest percentage losers.

Stocks that are making large moves like these are favorites among short-term traders because they can jump into these names and try to capture some of that massive volatility. Stocks that are making big-percentage moves either up or down are usually in play because their sector is becoming attractive or they have a major fundamental catalyst such as a recent earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade.

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Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success.

With that in mind, let's take a closer look at a several stocks under $10 that are making large moves to the upside today.

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EntreMed

EntreMed (ENMD) is a clinical-stage pharmaceutical company that develops therapeutic candidates for the treatment of cancer and inflammation. This stock is trading up 6.7% to $1.91 in recent trading.

Today's Range: $1.74-$1.94

52-Week Range: $1.23-$3.73

Volume: 122,000

Three-Month Average Volume: 59,505

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From a technical perspective, ENMD is ripping higher here right above some near-term support at $1.63 with above-average volume. This move is quickly pushing shares of ENMD within range of triggering a major breakout trade. That trade will hit if ENMD manages to take out its 50-day moving average at $1.95 with high volume.

Traders should now look for long-biased trades in ENMD as long as it's trending above today's low of $1.74 and then once it sustains a move or close above $1.95 with volume that hits near or above 59,505 shares. If that breakout triggers soon, then ENMD will set up to re-test or possibly take out its next major overhead resistance level at $2.40.

Neuralstem

Neuralstem (CUR) is a biotechnology company engaged in the development and commercialization of treatments for central nervous system disease based on transplanting human neural stem cells and the use of small molecule drugs. This stock is trading up 7.4% to $1.52 in recent trading.

Today's Range: $1.40-$1.52

52-Week Range: $0.42-$1.96

Volume: 684,000

Three-Month Average Volume: 459,303

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From a technical perspective, CUR is spiking significantly higher here right above its recent support level at $1.34 with above-average volume. This move is quickly pushing shares of CUR within range of triggering a near-term breakout trade. That trade will hit if CUR manages to take out some near-term overhead resistance at $1.59 with high volume.

Traders should now look for long-biased trades in CUR as long as it's trending above today's low of $1.40 and then once it sustains a move or close above $1.59 with volume that hits near or above 459,303 shares. If that breakout triggers soon, then CUR will set up to re-test or possibly take out its next major overhead resistance levels at $1.96 to $2.03. Any high-volume move above those levels will then put $2.50 into range for shares of CUR.

Synergetics USA

Synergetics USA (SURG) is a medical device company that designs, manufactures and markets innovative microsurgical instruments and other devices. This is trading up 3.8% to $3.22 in recent trading.

Today's Range: $3.07-$3.31

52-Week Range: $2.88-$5.75

Volume: 66,000

Three-Month Average Volume: 130,125

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From a technical perspective, SURG is spiking higher here right above some near-term support at $3.02 with lighter-than-average volume. This move has started to push shares of SURG back above its 50-day moving average at $3.20 and it's quickly trending within range of triggering a near-term breakout trade. That trade will hit if SURG manages to take out some near-term overhead resistance levels at $3.24 to $3.27 and then once it clears more resistance at $3.60 with high volume. At last check, SURG has hit an intraday high of $3.31 and volume is below its three-month average action of 130,125 shares.

Traders should now look for long-biased trades in SURG as long as it's trending above $3.02 and then once it sustains a move or close above those breakout levels with volume that hits near or above 130,125 shares. If that breakout hits soon, then SURG will set up to re-test or possibly take out its next major overhead resistance levels at its 200-day moving average of $4.32 to $5.

Opexa Therapeutics

Opexa Therapeutics (OPXA) is engaged in developing personalized cellular therapies with the potential to treat major illnesses, including multiple sclerosis. This stock is trading up 4.3% to $1.88 in recent trading.

Today's Range: $1.79-$1.91

52-Week Range: $1.07-$5.19

Volume: 244,000

Three-Month Average Volume: 387,623

From a technical perspective, OPXA is trending higher here and just starting to take out its 50-day moving average at $1.86 with decent upside volume. This move is quickly pushing shares of OPXA within range of triggering a major breakout trade. That trade will hit if OPXA manages to take out $1.92 to its 200-day at $2.05 and then once it clears more resistance at $2.25 with high volume. At last check, OPXA has hit an intraday high of $1.91 and volume is above 100,000 shares below its three-month average action of 387,623 shares.

Traders should now look for long-biased trades in OPXA as long as it's trending above today's low of $1.79 and then once it sustains a move or close above those breakout levels with volume that hits near or above 387,623 shares. If that breakout triggers soon, then this stock will set up to re-test or possibly take out its next major overhead resistance levels at $2.82 to $3.25. Any high-volume move above $3.25 could then send this stock past $4.

To see more stocks that are making notable moves higher today, check out the Stocks Under $10 Moving Higher portfolio on Stockpickr.

-- Written by Roberto Pedone in Madison, Wis.

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At the time of publication, author had no positions in stocks mentioned.

Roberto Pedone, based out of Madison, Wis., is an independent trader who focuses on technical analysis for small- and large-cap stocks, options, futures, commodities and currencies. Roberto studied international business at the Milwaukee School of Engineering, and he spent a year overseas studying business in Lubeck, Germany. His work has appeared on financial outlets including CNBC.com and Forbes.com. You can follow Pedone on Twitter at www.twitter.com/zerosum24 or @zerosum24.