Stock Quotes in this Article: APPY, CHTP, FOLD, BIOL

DELAFIELD, Wis. (Stockpickr) -- At Stockpickr, we track daily portfolios of stocks that are the biggest percentage gainers and the biggest percentage losers.

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Stocks that are making large moves like these are favorites among short-term traders because they can jump into these names and try to capture some of that massive volatility. Stocks that are making big-percentage moves either up or down are usually in play because their sector is becoming attractive or they have a major fundamental catalyst such as a recent earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade.

Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success.

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With that in mind, let's take a closer look at a several stocks under $10 that are making large moves to the upside today.

Amicus Therapeutics

Amicus Therapeutics (FOLD), a development-stage biopharmaceutical company, closed up 13% to $2.63 in Wednesday's trading session.

Wednesday's Range: $2.29-$2.64

52-Week Range: $2.06-$6.82

Wednesday's Volume: 441,000

Three-Month Average Volume: 359,998

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From a technical perspective, FOLD ripped higher here back above its 50-day moving average of $2.46 with above-average volume. This move is quickly pushing shares of FOLD within range of triggering a near-term breakout trade. That trade will hit if FOLD manages to take out some near-term overhead resistance levels at $2.79 to $2.85 with high volume.

Traders should now look for long-biased trades in FOLD as long as it's trending above its 50-day at $2.46 or above Wednesday's low of $2.29 and then once it sustains a move or close above those breakout levels with volume that hits near or above 359,998 shares. If that breakout triggers soon, then FOLD will set up to re-fill some of its previous gap down zone from June that started near $3.30.

Biolase

Biolase (BIOL) is a medical technology company that develops, manufactures and markets laser systems for dental and medical applications. This stock closed up 2.8% to $1.83 in Wednesday's trading session.

Wednesday's Range: $1.74-$1.87

52-Week Range: $1.16-$6.00

Wednesday's Volume: 311,000

Three-Month Average Volume: 669,633

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From a technical perspective, BIOL trended higher here right above some near-term support at $1.64 with lighter-than-average volume. This stock has been uptrending strong for the last month, with shares moving higher from its low of $1.15 to its intraday high of $1.87. During that move, shares of BIOL have been consistently making higher lows and higher highs, which is bullish technical price action. That move has now pushed shares of BIOL within range of triggering a near-term breakout trade. That trade will hit if BIOL manages to clear Wednesday's high of $1.87 and then once it takes out more near-term overhead resistance at $1.97 with high volume.

Traders should now look for long-biased trades in BIOL as long as it's trending above some key near-term support at $1.64 or at $1.50 and then once it sustains a move or close above those breakout levels with volume that hits near or above 669,633 shares. If that breakout triggers soon, then BIOL will set up to re-test or possibly take out its next major overhead resistance levels at $2.50 to its 50-day moving average at $2.93.

Venaxis

Venaxis (APPY) advances products that address unmet human diagnostic needs. This stock closed up 6.8% to $1.56 in Wednesday's trading session.

Wednesday's Range: $1.45-$1.59

52-Week Range: $1.15-$3.18

Wednesday's Volume: 1.85 million

Three-Month Average Volume: 802,962

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From a technical perspective, APPY jumped sharply higher here right above its 50-day moving average of $1.39 with heavy upside volume. This stock flirted with a near-term breakout trade on Wednesday, after it tested some resistance at $1.56, before closing right on that level. Shares of APPY are now starting to trend within range of triggering another near-term breakout trade. That trade will hit if APPY manages to take out some key overhead resistance levels at $1.62 to $1.70 with high volume.

Traders should now look for long-biased trades in APPY as long as it's trending above Wednesday's low of $1.45 or above its 50-day at $1.39 and then once it sustains a move or close above those breakout levels with volume that hits near or above 802,962 shares. If that breakout triggers soon, then APPY will set up to re-test or possibly take out its next major overhead resistance levels at $1.80 to its 200-day at $1.88. Any high-volume move above $1.88 will then give APPY a chance to trade north of $2.

Chelsea Therapeutics

Chelsea Therapeutics (CHTP) is a specialty pharmaceutical company focused on acquisition, development and commercialization of pharmaceutical products for the treatment of a variety of human diseases. This stock closed up 3.3% to $3.09 in Wednesday's trading session.

Wednesday's Range: $2.95-$3.10

52-Week Range: $0.73-$3.25

Wednesday's Volume: 1.15 million

Three-Month Average Volume: 1.13 million

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From a technical perspective, CHTP jumped higher here right above some near-term support at $2.90 with above-average volume. This stock has been uptrending strong for the last four months, with shares moving higher from its low of $1.68 to its recent high of $3.25. During that uptrend, shares of CHTP have been making mostly higher lows and higher highs, which is bullish technical price action. That move has now pushed shares of CHTP within range of triggering a major breakout trade. That trade will hit if CHTP manages to take out some near-term overhead resistance levels at $3.13 to its 52-week high at $3.25 with high volume.

Traders should now look for long-biased trades in CHTP as long as it's trending above support at $2.90 or above its 50-day at $2.74 and then once it sustains a move or close above those breakout levels with volume that hits near or above 1.13 million shares. If that breakout triggers soon, then CHTP will set up to enter new 52-week-high territory, which is bullish technical price action. Some possible upside targets off that breakout are its next major overhead resistance levels at $4.21 to $5.

To see more stocks that are making notable moves higher today, check out the Stocks Under $10 Moving Higher portfolio on Stockpickr.

-- Written by Roberto Pedone in Delafield, Wis.


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At the time of publication, author had no positions in stocks mentioned.

Roberto Pedone, based out of Delafield, Wis., is an independent trader who focuses on technical analysis for small- and large-cap stocks, options, futures, commodities and currencies. Roberto studied international business at the Milwaukee School of Engineering, and he spent a year overseas studying business in Lubeck, Germany. His work has appeared on financial outlets including

CNBC.com and Forbes.com. You can follow Pedone on Twitter at www.twitter.com/zerosum24 or @zerosum24.