Stock Quotes in this Article: ONTY, ZIOP, GALE, ACRX

WINDERMERE, Fla. (Stockpickr) -- At Stockpickr, we track daily portfolios of stocks that are the biggest percentage gainers and the biggest percentage losers.

Stocks that are making large moves like these are favorites among short-term traders because they can jump into these names and try to capture some of that massive volatility. Stocks that are making big-percentage moves either up or down are usually in play because their sector is becoming attractive or they have a major fundamental catalyst such as a recent earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade.

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Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success.

With that in mind, let's take a closer look at a several stocks under $10 that are making large moves to the upside today.

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Oncothyreon

Oncothyreon (ONTY) is a clinical-stage biopharmaceutical company. It develops and markets synthetic vaccines and small molecules that treat the lives and outcomes of cancer patients. This stock is trading up 5% to $2.27 in recent trading.

Today’s Range: $2.15-$2.28

52-Week Range: $1.71-$6.24

Volume: 336,000

Three-Month Average Volume: 699,088

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From a technical perspective, ONTY is bouncing higher here right above its 50-day moving average of $2.08 with lighter-than-average volume. This move has started to push shares of ONTY into breakout territory, since the stock has taken out some near-term overhead resistance levels at $2.20 to $2.26. At last check, ONY has hit an intraday high of $2.28, and volume is well below its three-month average action of 699,088 shares. This move is quickly pushing ONTY within range of triggering a major breakout trade. That trade will hit if ONTY manages to take out some near-term overhead resistance levels at $2.34 to $2.42 with high volume.

Traders should now look for long-biased trades in ONTY as long as it’s trending above today’s low of $2.14 or above $2.26, and then once it sustains a move or close above those breakout levels with volume that hits near or above 699,088 shares. If that breakout triggers soon, then ONTY will set up to re-fill some of its previous gap down zone from last December that started near $5.

Galena Biopharma

Galena Biopharma (GALE) is a biotechnology company focused on discovering, developing and commercializing innovative therapies addressing major unmet medical needs using targeted biotherapeutics. This stock is trading up 6.7% to $2.22 in recent trading.

Today’s Range: $2.08-$2.25

52-Week Range: $1.04-$2.43

Volume: 2.88 million

Three-Month Average Volume: 1.48 million

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From a technical perspective, GALE is soaring higher here and breaking out above some near-term overhead resistance levels at $2.15 to $2.18 with heavy upside volume. This move is quickly pushing shares of GALE within range of triggering another major breakout trade. That trade will hit if GALE manages to clear its next major overhead resistance levels at $2.35 to its 52-week high at $2.43 with high volume.

Traders should now look for long-biased trades in GALE as long as it’s trending above those first tier breakout levels of $2.16 to $2.18 and then once it sustains a move or close above those next major breakout levels at $2.35 to $2.43 with volume that hits near or above 1.48 million shares. If that breakout triggers soon, then GALE will set up to enter new 52-week-high territory above $2.43, which is bullish technical price action. Some possible upside targets off that move are $3 to $3.50.

Ziopharm Oncology

Ziopharm Oncology (ZIOP) is a biopharmaceutical company engaged in the development and commercialization of small molecule and synthetic biology approaches to new cancer therapies. This stock is trading up 13.5% to $1.84 in recent trading.

Today’s Range: $1.70-$1.86

52-Week Range: $1.49-$6.33

Volume: 2.98 million

Three-Month Average Volume: 2.12 million

Shares of ZIOP are soaring higher here after the company reported encouraging results from a preclinical trial of cancer therapy Ad-RTS-MiL-12. The drug is designed to enable the controlled delivery of a protein important for immune response to cancer.

From a technical perspective, ZIOP is gapping sharply higher here off extremely oversold territory with heavy upside volume. This stock recently gapped down big from over $5 to around $1.75 with heavy downside volume. Following that gap, shares of ZIOP went on to hit its recent 52-week low of $1.49. That gap down pushed shares of ZIOP into extremely oversold territory, since the stock’s relative strength index dipped below 30. Shares of ZIOP are now quickly moving within range of triggering a major breakout trade. That trade will hit if ZIOP manages to take out its gap down day high of $2.11 with high volume.

Traders should now look for long-biased trades in ZIOP as long as it’s trending above today’s low of $1.70, and then once it sustains a move or close above that gap down day high of $2.11 with volume that hits near or above 2.12 million shares. If that breakout triggers soon, then ZIOP will set up to re-fill some of its previous gap down zone from late March that started just above $5.

AcelRx Pharmaceuticals

AcelRx Pharmaceuticals (ACRX) is a U.S.-based pharmaceutical company, which develops and commercializes therapies for the treatment of pain. This stock is trading up 7.5% to $5.65 in recent trading.

Today’s Range: $5.31-$5.67

52-Week Range: $2.27-$5.97

Volume: 348,000

Three-Month Average Volume: 278,354

Shares of ACRX are ripping higher today after Jefferies initiated the stock with a buy rating and $8 per share price target.

From a technical perspective, ACRX is bouncing strong here right above its 50-day moving average of $5.14 with above-average volume. This move has started to push shares of ACRX into breakout territory, since the stock has moved above some near-term overhead resistance at $5.52 to $5.62. Shares of ACRX are now quickly moving within range of triggering another major breakout trade. That trade will hit if ACRX manages to take out its 52-week high at $5.97 with high volume.

Traders should now look for long-biased trades in ACRX as long as it’s trending above $5.52 or $5.62, and then once it sustains a move or close above its 52-week high at $5.97 with volume that hits near or above 278,354 shares. If that breakout triggers soon, then ACRX will set up to enter new 52-week-high territory and all-time high territory, which is bullish technical price action. Some possible upside targets off that breakout are $7 to $8 in the near future.

To see more stocks that are making notable moves higher today, check out the Stocks Under $10 Moving Higher portfolio on Stockpickr.

-- Written by Roberto Pedone in Winderemere, Fla.

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At the time of publication, author had no positions in stocks mentioned.

Roberto Pedone, based out of Windermere, Fla., is an independent trader who focuses on technical analysis for small- and large-cap stocks, options, futures, commodities and currencies. Roberto studied international business at the Milwaukee School of Engineering, and he spent a year overseas studying business in Lubeck, Germany. His work has appeared on financial outlets including CNBC.com and Forbes.com. You can follow Pedone on Twitter at www.twitter.com/zerosum24 or @zerosum24.