Stock Quotes in this Article: ACHN, ARNA, MELA, THLD

WINDERMERE, Fla. (Stockpickr) -- At Stockpickr, we track daily portfolios of stocks that are the biggest percentage gainers and the biggest percentage losers.

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Stocks that are making large moves like these are favorites among short-term traders because they can jump into these names and try to capture some of that massive volatility. Stocks that are making big-percentage moves either up or down are usually in play because their sector is becoming attractive or they have a major fundamental catalyst such as a recent earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade.

Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success.

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With that in mind, let's take a closer look at a several stocks under $10 that are making large moves to the upside today.

Arena Pharmaceuticals (ARNA)

This is a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing oral drugs that target G protein-coupled receptors. This stock is trading up 5.9% to $9.74 in recent trading.

Today's Range: $9.31-$9.83

52-Week Range: $1.54-$13.50

Volume: 15.06 million

Three-Month Average Volume: 8.13 million

From a technical perspective, ARNA is ripping higher here right above its 50-day moving average of $8.73 with heavy upside volume. This stock has been uptrending for the last two months, with shares moving higher from its low of $7.09 to its intraday high of $9.83. During that move, shares of ARNA have been mostly making higher lows and higher highs, which is bullish technical price action. That move has now pushed ARNA within range of triggering a breakout trade. That trade will hit if ARNA takes out some key overhead resistance levels at $9.57 to $10.05 with high volume.

Traders should now look for long-biased trades in ARNA as long as it's trending above $9, and then once it sustains a move or close above those breakout levels with volume that hits near or above 8.13 million shares. If that breakout triggers soon, then ARNA will set up to re-test or possibly take out its next major overhead resistance levels at $10.40 to $12.07.

Achillion Pharmaceuticals (ACHN)

This is a biopharmaceutical company which focuses on the discovery, development and commercialization of innovative treatments for infectious diseases. This stock is trading up 5.4% to $9.04 in recent trading.

Today's Range: $8.52-$9.05

52-Week Range: $5.42-$12.95

Volume: 701,000

Three-Month Average Volume: 987,190

From a technical perspective, ACHN is ripping higher here right above its 50-day moving average of $8.29 with decent volume. This move is quickly pushing shares of ACHN within range of triggering a near-term breakout trade. That trade will hit if ACHN manages to clear some near-term overhead resistance at $9.79 with high volume.

Traders should now look for long-biased trades in ACHN as long as it's trending above its 50-day at $8.29, and then once it sustains a move or close above $9.79 with volume that hits near or above 987,190 shares. If that breakout hits soon, then ACHN will set up to re-test or possibly take out its next major overhead resistance levels at $11 to $11.36.

Threshold Pharmaceuticals (THLD)

This is a biotechnology company focused on the discovery and development of drugs targeting the microenvironment of solid tumors as novel treatments for patients living with cancer. The stock is trading up 5.8% to $4.50 in recent trading.

Today's Range: $4.24-$4.58

52-Week Range: $1.27-$9.28

Volume: 884,000

Three-Month Average Volume: 942,030

From a technical perspective, THLD is bouncing higher here right off its 50-day moving average of $4.32 with decent volume. This stock has been trending sideways for the last two months, with shares moving between $3.94 on the downside and $5 on the upside. This move today is quickly pushing THLD within range of breaking out above the upper-end of its recent sideways trading pattern. That breakout will hit if THLD manages to take out some near-term overhead resistance levels at $4.58 to $5 with high volume.

Traders should now look for long-biased trades in THLD as long as it's trending above some key near-term support levels at $4.14 to $4.15, and then once it sustains a move or close above those breakout levels with volume that hits near or above 942,030 shares. If that breakout triggers soon, then THLD will set up to re-test or possibly take out its next major overhead resistance levels at $5.90 to its 200-day moving average at $6.37.

Mela Sciences (MELA)

This is a medical device company engaged in designing and development of a non-invasive, point-of-care instrument to assist in the early diagnosis of melanoma. This stock is trading up 5% to $1.89 in recent trading.

Today's Range: $1.80-$1.95

52-Week Range: $1.65-$5.13

Volume: 1.14 million

Three-Month Average Volume: 194,475

From a technical perspective, MELA is bouncing higher here right above its 52-week low of $1.65 with monster upside volume. This stock has been downtrending badly for the last two months, with shares plunging from a high of $3.15 to its recent low of $1.65. During that move, shares of MELA have been consistently making lower highs and lower lows, which is bearish technical price action. That move has pushed MELA into oversold territory, since its relative strength index (RSI) reading was well below 30. Oversold can always get more oversold, but it's also an area where a stock can experience a powerful bounce higher.

Traders should now look for long-biased trades in MELA as long as it's trending above its 52-week low of $1.65, and then once it sustains a move or close above some near-term breakout levels at $1.90 to $2.10 with volume that hits near or above 194,475 shares. If that breakout triggers soon, then MELA will set up to re-test or possibly take out its next major overhead resistance levels at $2.25 to its 50-day moving average at $2.33. Any move above $2.33 would then put $2.50 into focus for shares of MELA.

To see more stocks that are making notable moves higher today, check out the Stocks Under $10 Moving Higher portfolio on Stockpickr.

-- Written by Roberto Pedone in Winderemere, Fla.

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At the time of publication, author had no positions in stocks mentioned.

Roberto Pedone, based out of Windermere, Fla., is an independent trader who focuses on technical analysis for small- and large-cap stocks, options, futures, commodities and currencies. Roberto studied international business at the Milwaukee School of Engineering, and he spent a year overseas studying business in Lubeck, Germany. His work has appeared on financial outlets including CNBC.com and Forbes.com. You can follow Pedone on Twitter at www.twitter.com/zerosum24 or @zerosum24.