Stock Quotes in this Article: ENDP, GENT, OSIR, INSY

DELAFIELD, Wis. (Stockpickr) -- Professional traders running mutual funds and hedge funds don't just look at a stock's price moves; they also track big changes in volume activity. Often when above-average volume moves into an equity, it precedes a large spike in volatility.

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Major moves in volume can signal unusual activity, such as insider buying or selling -- or buying or selling by "superinvestors."

Unusual volume can also be a major signal that hedge funds and momentum traders are piling into a stock ahead of a catalyst. These types of traders like to get in well before a large spike, so it's always a smart move to monitor unusual volume. That said, remember to combine trend and price action with unusual volume. Put them all together to help you decipher the next big trend for any stock.

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With that in mind, let's take a look at several stocks rising on unusual volume today.

Gentium

Gentium (GENT) is engaged in the research and development of drugs derived from DNA and DNA molecules. This stock closed up 3.7% to $18.66 in Monday's trading session.

Monday's Volume: 1.17 million

Three-Month Average Volume: 58,152

Volume % Change: 1576%

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From a technical perspective, GENT jumped higher here right above some near-term support at $17.20 with monster upside volume. This stock recently gapped up sharply higher from $10 to $15.90 with heavy upside volume. Following that move, shares of GENT have continued to uptrend from $13 to its recent high of $19.50. That move is quickly pushing shares of GENT within range of triggering a big breakout trade. That trade will hit if GENT manages to take out some near-term overhead resistance at $18.80 to its 52-week high at $19.50 with high volume.

Traders should now look for long-biased trades in GENT as long as it's trending above $17.20 and then once it sustains a move or close above those breakout levels with volume that hits near or above 58,152 shares. If that breakout hits soon, then GENT will set up to enter new 52-week-high territory, which is bullish technical price action. Some possible upside targets off that breakout are $24 to $25.

Endo Health Solutions

Endo Health Solutions (ENDP) researches, develops, sells and markets branded and generic prescription pharmaceuticals used to treat and manage pain. This stock closed up 1.5% to $37.39 in Monday's trading session.

Monday's Volume: 2.37 million

Three-Month Average Volume: 1.64 million

Volume % Change: 52%

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From a technical perspective, ENDP jumped higher here right above some near-term support at $36.17 with above-average volume. This stock has been trending sideways inside of a consolidation pattern for the last two months and change, with shares moving between $36.17 on the downside and $40.19 on the upside. Shares of ENDP are now starting bounce higher right off the lower-end of that recent range with rising volume.

Traders should now look for long-biased trades in ENDP as long as it's trending above support at $36.17 and then once it sustains a move or close above is 50-day moving average at $38.06 with volume that hits near or above 1.64 million shares. If we get that move soon, then ENDP will set up to re-test or possibly take out its 52-week high at $40.19. Any high-volume move above that level will then put $42 to $44 into range for shares of ENDP.

Osiris Therapeutics

Osiris Therapeutics (OSIR) is a stem cell therapeutic company focused on developing and marketing products to treat medical conditions in the inflammatory, orthopedic and cardiovascular areas. This stock closed up 2.6% at $20 in Monday's trading session.

Monday's Volume: 742,000

Three-Month Average Volume: 319,625

Volume % Change: 95%

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From a technical perspective, OSIR trended higher here with above-average volume. This stock recently gapped up huge from around $10 to $26 with monster upside volume. Following that gap up, shares of OSIR have pulled back to its intraday low on Monday of $18.50 with above-average volume. Shares of OSIR might have now put in a short-term bottom as the stock moves within range of triggering a near-term breakout trade. That trade will hit if OSIR manages to take out Monday's high of $20.47 to $22 with high volume.

Traders should now look for long-biased trades in OSIR as long as it's trending above Monday's low of $18.50 and then once it sustains a move or close above those breakout levels with volume that's near or above 319,625 shares. If that breakout hits soon, then OSIR will set up to re-test or possibly take out its 52-week high at $27.40.

Insys Therapeutics

Insys Therapeutics (INSY) is a specialty pharmaceutical company that develops and commercializes supportive care products that target the unmet needs of cancer patients, with an initial focus on cancer-supportive care. This stock closed up 2.8% at $24.82 in Monday's trading session.

Monday's Volume: 208,000

Three-Month Average Volume: 100,780

Volume % Change: 78%

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From a technical perspective, INSY trended up notably higher here right off some near-term support at $24 with above-average volume. This stock has been uptrending incredibly strong for the last three months and change, with shares moving higher from its low of $9.30 to its recent high of $26.71. During that monster move, shares of INSY have been consistently making higher lows and higher highs, which is bullish technical price action. That move has now pushed shares of INSY within range of triggering a near-term breakout trade. That trade will hit if INSY manages to take out its all-time high at $26.71 with high volume.

Traders should now look for long-biased trades in INSY as long as it's trending above some key near-term support levels at $24 to $22 and then once it sustains a move or close above its all-time high at $26.71 with volume that's near or above 100,780 shares. If that breakout hits soon, then INSY will set up to enter new all-time-high territory, which is bullish technical price action. Some possible upside targets off that breakout $30 to $35.

To see more stocks rising on unusual volume, check out the Stocks Rising on Unusual Volume portfolio on Stockpickr.

-- Written by Roberto Pedone in Delafield, Wis.

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At the time of publication, author had no positions in stocks mentioned.

Roberto Pedone, based out of Delafield, Wis., is an independent trader who focuses on technical analysis for small- and large-cap stocks, options, futures, commodities and currencies. Roberto studied international business at the Milwaukee School of Engineering, and he spent a year overseas studying business in Lubeck, Germany. His work has appeared on financial outlets including CNBC.com and Forbes.com. You can follow Pedone on Twitter at www.twitter.com/zerosum24 or @zerosum24.