Stock Quotes in this Article: DCTH, VICL, ACRX

WINDERMERE, Fla. (Stockpickr) -- At Stockpickr, we track daily portfolios of stocks that are the biggest percentage gainers and the biggest percentage losers.

Stocks that are making large moves like these are favorites among short-term traders because they can jump into these names and try to capture some of that massive volatility. Stocks that are making big-percentage moves either up or down are usually in play because their sector is becoming attractive or they have a major fundamental catalyst such as a recent earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade.

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Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success.

With that in mind, let's take a closer look at a several stocks that are making large moves to the upside today.

>>4 Breakout Buys for January -- and One Sell

AcelRx Pharmaceuticals

AcelRx Pharmaceuticals (ACRX), a pharmaceutical company that develops and commercializes therapies for the treatment of pain, is trading up 5.5% to $4.79 in recent trading.

Today’s Range: $4.49-$4.89

52-Week Range: $2.27-$5.25

Volume: 450,000

Three-Month Average Volume: 275,797

From a technical perspective, ACRX is ripping higher here right above some near-term support at $4.23 with above-average volume. This stock has been uptrending strongly for the last month and change, with shares moving higher from its low of $3.30 to its intraday high of $4.89. During that move, shares of ACRX have been consistently making higher lows and higher highs, which is bullish technical price action. That move has now pushed ACRX within range of triggering a major breakout trade. That trade will hit if ACRX takes out some near-term overhead resistance levels at $4.85 to $5.25 with high volume.

Traders should now look for long-biased trades in ACRX as long as it’s trending above its 50-day at $3.92, and then once it sustains a move or close above those breakout levels with volume that hits near or above 275,797 shares. If that breakout triggers soon, then ACRX will set up to enter new 52-week-high territory above $5.25, which is bullish price action. Some possible upside targets off that breakout are $6 to $6.50 in the near future.

Vical

Vical (VICL) researches and develops biopharmaceutical products based on its patented DNA delivery technologies for the prevention and treatment of serious or life-threatening diseases. This stock is trading up 8.4% to $3.61 in recent trading.

Today’s Range: $3.30-$3.61

52-Week Range: $2.61-$4.74

Volume: 469,000

Three-Month Average Volume: 604,982

From a technical perspective, VICL is soaring higher here back above its 200-day moving average of $3.35 with decent volume. This move is quickly pushing VICL within range of triggering a near-term breakout trade. That trade will hit if VICL manages to take out some near-term overhead resistance levels at $3.69 to $3.93 with high volume.

Traders should now look for long-biased trades in VICL as long as it’s trending above its 200-day at $3.35, and then once it sustains a move or close above those breakout levels with volume that hits near or above 604,982 shares. If that breakout hits soon, then VICL will set up to re-test or possibly take out its next major overhead resistance levels at $4.40 to $4.74. Any move above $4.74 would then push VICL into new 52-week high territory, which is bullish technical price action.

Delcath Systems

Delcath Systems (DCTH) is a development stage, specialty pharmaceutical and medical device company focused on oncology, initially cancers in the liver. This stock is trading up 8.4% to $1.54 in recent trading.

Today’s Range: $1.40-$1.55

52-Week Range: $1.01-$4.74

Volume: 3.25 million

Three-Month Average Volume: 1.02 million

From a technical perspective, DCTH is ripping higher here right above its 50-day moving average of $1.35 with monster upside volume. This stock has been uptrending for the last month, with shares moving higher from its recent low of $1.16 to its intraday high of $1.55. During that move, shares of DCTH have been consistently making higher lows and higher highs, which is bullish technical price action. That move has now pushed DCTH within range of triggering a near-term breakout trade. That trade will hit if DCTH manages to clear some near-term overhead resistance at $1.67 with high volume.

Traders should now look for long-biased trades in DCTH as long as it’s trending above its 50-day at $1.35, and then once it sustains a move or close $1.67 with volume that hits near or above 1.02 million shares. If that breakout triggers soon, then DCTH will set up to re-test or possibly take out its next major overhead resistance levels at $1.84 to $2.24.

To see more stocks that are making notable moves higher today, check out the Stocks Under $10 Moving Higher portfolio on Stockpickr.

-- Written by Roberto Pedone in Winderemere, Fla.


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At the time of publication, author had no positions in stocks mentioned.

Roberto Pedone, based out of Windermere, Fla., is an independent trader who focuses on technical analysis for small- and large-cap stocks, options, futures, commodities and currencies. Roberto studied international business at the Milwaukee School of Engineering, and he spent a year overseas studying business in Lubeck, Germany. His work has appeared on financial outlets including

CNBC.com and Forbes.com. You can follow Pedone on Twitter at www.twitter.com/zerosum24 or @zerosum24.