Stock Quotes in this Article: APPY, CRIS, ISR, ZLTQ

 DELAFIELD, Wis. (Stockpickr) -- At Stockpickr, we track daily portfolios of stocks that are the biggest percentage gainers and the biggest percentage losers.

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Stocks that are making large moves like these are favorites among short-term traders because they can jump into these names and try to capture some of that massive volatility. Stocks that are making big-percentage moves either up or down are usually in play because their sector is becoming attractive or they have a major fundamental catalyst such as a recent earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade.

Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success.

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With that in mind, let's take a closer look at a several stocks under $10 that are making large moves to the upside today.

Venaxis

Venaxis (APPY) advances products that address unmet human diagnostic needs. This stock closed up 6.2% to $1.37 in Thursday's trading session.

Thursday's Range: $1.27-$1.40

52-Week Range: $1.15-$3.18

Thursday's Volume: 1.33 million

Three-Month Average Volume: 878,238

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From a technical perspective, APPY ripped higher here right off some near-term support at $1.25 and back above its 50-day moving average at $1.35 with above-average volume. This move is quickly pushing shares of APPY within range of triggering a major breakout trade. That trade will hit if APPY manages to take out some near-term overhead resistance levels at $1.41 to $1.45 with high volume.

Traders should now look for long-biased trades in APPY as long as it's trending above support at $1.25 and then once it sustains a move or close above those breakout levels with volume that hits near or above 878,238 shares. If that breakout hits soon, then APPY will set up to re-test or possibly take out its next major overhead resistance levels at $1.70 to $1.80. Any high-volume move above those levels will then put its next major resistance levels at $1.94 to its 200-day at $2.03 into range for shares of APPY.

IsoRay

IsoRay (ISR) is a medical technology company. This stock closed up 12.5% to 59 cents per share in Thursday's trading session.

Thursday's Range: $0.54-$0.60

52-Week Range: $0.35-$1.14

Thursday's Volume: 505,000

Three-Month Average Volume: 83,197

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From a technical perspective, ISR skyrocketed higher here right off its 50-day moving average of 55 cents per share with heavy upside volume. This move is quickly pushing shares of ISR within range of triggering a major breakout trade above a key descending trendline. That trade will hit if ISR manages to take out some near-term overhead resistance levels at 61 cents to 63 cents per share with high volume.

Traders should now look for long-biased trades in ISR as long as it's trending above its 50-day at 55 cents per share and then once it sustains a move or close above those breakout levels with volume that hits near or above 83,197 shares. If that breakout triggers soon, then ISR will set up to re-test or possibly take out its next major overhead resistance levels at 70 cents to 76 cents per share. Any high-volume move above 76 cents per share will then put its next major overhead resistance levels at 85 cents to 95 cents per share within range for shares of ISR.

Curis

Curis (CRIS) is a drug discovery and development company that is committed to leveraging its innovative signaling pathway drug technologies in seeking to develop next generation targeted cancer therapies. This stock closed up 6.2% to $3.92 in Thursday's trading session.

Thursday's Range: $3.61-$3.92

52-Week Range: $2.66-$5.16

Thursday's Volume: 455,000

Three-Month Average Volume: 532,070

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From a technical perspective, CRIS ripped higher here right off its 50-day moving average of $3.61 with decent upside volume. This stock has been uptrending strong for the last month and change, with shares moving higher from its low of $3.15 to its recent high of $3.93. During that move, shares of CRIS have been making mostly higher lows and higher highs, which is bullish technical price action. That move has now pushed shares of CRIS within range of triggering a major breakout trade. That trade will hit if CRIS manages to take out some near-term overhead resistance levels at $3.93 to $3.94 with high volume.

Traders should now look for long-biased trades in CRIS as long as it's trending above its 50-day at $3.61 or its 200-day at $3.46 and then once it sustains a move or close above those breakout levels with volume that hits near or above 532,070 shares. If that breakout hits soon, then CRIS will set up to re-test or possibly take out its next major overhead resistance levels at $4.50 to its 52-week high at $5.16. Any high-volume move above those levels will then put its next major overhead resistance levels at $5.50 to $5.65 into range for shares of CRIS.

Zeltiq Aesthetics

Zeltiq Aesthetics (ZLTQ) develops and commercializes medical products such as CoolSculpting System, a non-invasive product for the selective reduction of body fat. This stock closed up 4.7% to $6.20 in Thursday's trading session.

Thursday's Range: $5.96-$6.30

52-Week Range: $3.20-$7.08

Thursday's Volume: 254,000

Three-Month Average Volume: 75,457

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From a technical perspective, ZLTQ spiked sharply higher here right above its 50-day moving average of $5.71 with heavy upside volume. This move is quickly pushing shares of ZLTQ within range of triggering a major breakout trade. That trade will hit if ZLTQ manages to take out some near-term overhead resistance levels at $6.58 to $6.70 and then once it clears some past resistance at $7.08 with high volume.

Traders should now look for long-biased trades in ZLTQ as long as it's trending above its 50-day at $5.71 and then once it sustains a move or close above those breakout levels with volume that hits near or above 75,457 shares. If that breakout triggers soon, then ZLTQ will set up to re-test or possibly take out its next major overhead resistance levels at $9 to $10.

To see more stocks that are making notable moves higher today, check out the Stocks Under $10 Moving Higher portfolio on Stockpickr.

-- Written by Roberto Pedone in Delafield, Wis.

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At the time of publication, author had no positions in stocks mentioned.

Roberto Pedone, based out of Delafield, Wis., is an independent trader who focuses on technical analysis for small- and large-cap stocks, options, futures, commodities and currencies. Roberto studied international business at the Milwaukee School of Engineering, and he spent a year overseas studying business in Lubeck, Germany. His work has appeared on financial outlets including CNBC.com and Forbes.com. You can follow Pedone on Twitter at www.twitter.com/zerosum24 or @zerosum24.